Article
Polymorphisms in miRNA processing genes and their role in osteosarcoma risk.
Pediatric blood & cancer - 1 May 2015
Bilbao-Aldaiturriaga Nerea, Gutierrez-Camino Angela, Martin-Guerrero Idoia, Pombar-Gomez Maria, Zalacain-Diez Marta, Patiño-Garcia Ana, Lopez-Lopez Elixabet, Garcia-Orad Africa
Abstract excerpt
BACKGROUND: The possible associations between genetic variants and osteosarcoma risk have been analyzed without conclusive results. Those studies were focused mainly on genes of biologically plausible pathways. However, recently, another pathway has acquired relevance in cellular transformation and tumorigenesis, the microRNA (miRNA) processing pathway. Dysregulation of the expression levels of genes in this...
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