Article
MicroRNA polymorphisms as markers of risk, prognosis and treatment response in hematological malignancies.
Critical reviews in oncology/hematology - 1 Jan 2015
Dzikiewicz-Krawczyk Agnieszka
Abstract excerpt
MicroRNA dysregulation is a common event in hematological malignancies. Apart from genomic and epigenetic alterations, miRNA networks may be disturbed by polymorphisms in the miRNA regulatory pathway (miRSNPs). In this review we provide an overview of three categories of miRSNPs: (1) SNPs in genes involved in miRNA biogenesis and processing; (2) SNPs in miRNA genes; and (3) SNPs in miRNA binding sites in target...
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