Article
XPO5 genetic polymorphisms in cancer risk and prognosis.
Pharmacogenomics - 1 Jun 2018
Patrão Ana Sofia, Dias Francisca, Teixeira Ana Luísa, Maurício Joaquina, Medeiros Rui
Abstract excerpt
miRNAs are small noncoding RNA molecules that have a very important role in gene expression regulation and, therefore, in cell homeostasis. SNPs in certain miRNA-related genes have been shown to influence cancer risk and prognosis. miRNA cellular processing is complex and involves multiple proteins. XPO5 is a key factor in this process as it is responsible for the nuclear export of the precursor pre-miRNA to the...
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