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Article

Gene-Gene Interaction Among WNT Genes for Oral Cleft in Trios.

Genetic epidemiology - 1 Jul 2015

Li Qing, Kim Yoonhee, Suktitipat Bhoom, Hetmanski Jacqueline B, Marazita Mary L, Duggal Priya, Beaty Terri H, Bailey-Wilson Joan E

Abstract excerpt

Genome-wide association studies (GWAS) for nonsyndromic cleft lip with or without cleft palate (CL/P) have identified multiple genes as important in the etiology of this common birth defect. We performed a candidate gene/pathway analysis explicitly considering gene-gene (G × G) interaction to further explore the etiology of CL/P. Animal models have shown the WNT signaling pathway plays an important role in...

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Identifiers

PMID: 25663376
DOI: 10.1002/gepi.21888
PMCID: PMC4469492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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