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Article

A native outer membrane vesicle vaccine confers protection against meningococcal colonization in human CEACAM1 transgenic mice.

Vaccine - 10 Mar 2015

Pajon Rolando, Buckwalter Carolyn M, Johswich Kay O, Gray-Owen Scott D, Granoff Dan M

Abstract excerpt

BACKGROUND: The effect of protein-based meningococcal vaccines on prevention of nasopharyngeal colonization has been difficult to investigate experimentally because a reliable animal colonization model did not exist. METHODS: Human CEACAM1 transgenic mice, which can be colonized by meningococci, were immunized IP with one of two meningococcal native outer membrane vesicle (NOMV) vaccines prepared from mutants...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Neisseria meningitidis

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Source

Open in PubMed Open full text

Identifiers

PMID: 25662856
DOI: 10.1016/j.vaccine.2015.01.057
PMCID: PMC4361389

Genes

CEACAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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