Article
Adjuvant effects elicited by novel oligosaccharide variants of detoxified meningococcal lipopolysaccharides on Neisseria meningitidis recombinant PorA protein: a comparison in mice.
PloS one - 1 Jan 2014
Mehta Ojas H, Norheim Gunnstein, Hoe J Claire, Rollier Christine S, Nagaputra Jerry C, Makepeace Katherine, Saleem Muhammad, Chan Hannah, Ferguson David J P, Jones Claire, Sadarangani Manish, Hood Derek W, Feavers Ian, Derrick Jeremy P, Pollard Andrew J, Moxon E Richard
Abstract excerpt
Neisseria meningitidis lipopolysaccharide (LPS) has adjuvant properties that can be exploited to assist vaccine immunogenicity. The modified penta-acylated LPS retains the adjuvant properties of hexa-acylated LPS but has a reduced toxicity profile. In this study we investigated whether two modifi...
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