A cis-eQTL in PFKFB2 is associated with diabetic nephropathy, adiposity and insulin secretion in American Indians.

doi:10.1093/hmg/ddv040

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Article

A cis-eQTL in PFKFB2 is associated with diabetic nephropathy, adiposity and insulin secretion in American Indians.

Human molecular genetics - 15 May 2015

Muller Yunhua L, Piaggi Paolo, Hanson Robert L, Kobes Sayuko, Bhutta Shujera, Abdussamad Maryam, Leak-Johnson Tennille, Kretzler Matthias, Huang Ke, Weil E Jennifer, Nelson Robert G, Knowler William C, Bogardus Clifton, Baier Leslie J

Abstract excerpt

A prior genome-wide association study (GWAS) in Pima Indians identified a variant within PFKFB2 (rs17258746) associated with body mass index (BMI). PFKFB2 encodes 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase isoform 2, which plays a role in glucose metabolism. To follow-up on the GWAS, tag SNPs across PFKFB2 were genotyped in American Indians (AI) who had longitudinal data on BMI (n = 6839), type 2...

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PMID: 25662186
DOI: 10.1093/hmg/ddv040
PMCID: PMC4416128

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PFKFB2

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