Article
IGF2BP2 and IGF2 genetic effects in diabetes and diabetic nephropathy.
Journal of diabetes and its complications - 1 Jan 2000
Gu Tianwei, Horová Eva, Möllsten Anna, Seman Norhashimah Abu, Falhammar Henrik, Prázný Martin, Brismar Kerstin, Gu Harvest F
Abstract excerpt
OBJECTIVE: The IGF2BP2 gene is located on chromosome 3q27.2 within a region linked to type 1 diabetes (T1D), type 2 diabetes (T2D) and diabetic nephropathy (DN). Its protein functionally binds to 5'-UTR of the imprinting IGF2 gene. The present study aims to evaluate the IGF2BP2-IGF2 genetic effects in diabetes and DN. MATERIALS AND METHODS: Three cohorts including T1D with and without DN (n=1139) of European...
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