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Freedom and constraint in engineered noncolinear polyketide assembly lines.

Chemistry & biology - 19 Feb 2015

Sugimoto Yuki, Ishida Keishi, Traitcheva Nelly, Busch Benjamin, Dahse Hans-Martin, Hertweck Christian

Abstract excerpt

Many pharmacologically important natural products are assembled by modular type I polyketide synthases (PKS), which typically act in a unidirectional fashion. The synthases producing the unusual nitro-substituted polyketides neoaureothin (nor, also called spectinabilin) and aureothin (aur) are exceptional, as they employ individual modules iteratively. Here, we investigate the plasticity of the nor PKS and the...

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PMID: 25660274
DOI: 10.1016/j.chembiol.2014.12.014

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