Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analysis of the aureothin iterative type I polyketide synthase.

Chembiochem : a European journal of chemical biology - 1 May 2005

He Jing, Hertweck Christian

Abstract excerpt

The modular-type polyketide synthase (PKS) that is involved in aureothin (aur) biosynthesis represents one of the first examples in which a single PKS module (AurA) is used in an iterative fashion. Here we report on the heterologous expression of an engineered AurAB fusion protein that unequivocally proves the iterative nature of AurA. In addition, point mutations reveal that aur PKS module 4 participates in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Chromones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Polyketide Synthases

Share to Protein Structure, Tertiary

Source

Identifiers

PMID: 15812854
DOI: 10.1002/cbic.200400333

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of the aureothin iterative type I polyketide synthase.PMID 15812854Read ↗

Interchenar retrotransfer of aureothin intermediates in an iterative polyketide synthase module.Semantic proximity Read ↗

Rational Design of Modular Polyketide Synthases: Morphing the Aureothin Pathway into a Luteoreticulin Assembly LineSemantic proximity Read ↗

Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenasesSemantic proximity Read ↗

Freedom and constraint in engineered noncolinear polyketide assembly lines.Semantic proximity Read ↗

An Iterative Module in the Azalomycin F Polyketide Synthase Contains a Switchable Enoylreductase Domain.Semantic proximity Read ↗

Cloning and characterization of a polyketide synthase gene cluster involved in biosynthesis of a proposed angucycline-like polyketide auricin in Streptomyces aureofaciens CCM 3239.Semantic proximity Read ↗

Evidence for a protein-protein interaction motif on an acyl carrier protein domain from a modular polyketide synthase.Semantic proximity Read ↗

Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol PolyketidesSemantic proximity Read ↗

Unraveling the iterative type I polyketide synthases hidden in StreptomycesSemantic proximity Read ↗

Extensive Alanine Scanning of Loop Regions in Ketosynthase Domains Identifies Non-Active Site Mutations with Drastic Effects on Polyketide Biosynthesis.Semantic proximity Read ↗

Systematic analysis of the kalimantacin assembly line NRPS module using an adapted targeted mutagenesis approach.Semantic proximity Read ↗

A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.