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Article

Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases

2 Sept 2019

Abstract excerpt

Polyketides produced by modular type I polyketide synthases (PKSs) play eminent roles in the development of medicines. Yet, the production of structural analogs by genetic engineering poses a major challenge. We report an evolution-guided morphing of modular PKSs inspired by recombination processes that lead to structural diversity in nature. By deletion and insertion of PKS modules we interconvert the assembly...

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PMID: 31477708
DOI: 10.1038/s41467-019-11896-1

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