Article

Dysregulation of MMP-2 and MMP-9 in Post-COVID-19 and IPF: Correlations with Systemic Inflammation and Endothelial Dysfunction

2025-12-11

Abstract excerpt

<h4>Background: </h4> /Objectives: Post-COVID-19 pulmonary fibrosis (PCPF) and idiopathic pul-monary fibrosis (IPF) show clinical parallels, suggesting overlapping pathogenesis. This study investigated the dysregulation of key proteases, matrix metalloproteinases-2 and -9 (MMP-2/9), and associated inflammatory and endothelial markers in both conditions. <h4>Methods:</h4> We analyzed MMP-2 and MMP-9 gene expression...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e7743beb-9346-5ae8-bab4-b77d32e9253e
DOI: 10.20944/preprints202512.0935.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dysregulation of MMP-2 and MMP-9 in Post-COVID-19 and IPF: Correlations with Systemic Inflammation and Endothelial DysfunctionDOI 10.20944/preprints202512.0935.v1Read

Sustained activation of toll-like receptor 9 induces an invasive phenotype in lung fibroblasts: possible implications in idiopathic pulmonary fibrosis.Semantic proximity Read

Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samplesSemantic proximity Read

Immunological mechanisms and therapeutic approaches in pulmonary fibrosis.Semantic proximity Read

ACE2 expression in PBMC and plasma markers of vasculopathy and fibrosis during early COVID – implications for post-COVID conditionsSemantic proximity Read

Matrix Metalloproteinases and Their Inhibitors in Chronic Obstructive Pulmonary Disease.Semantic proximity Read

Evolving Perspectives on Innate Immune Mechanisms of IPFSemantic proximity Read

Anti-Fibrotic Agents Could Be the Game Changer for Post‑COVID Pulmonary Fibrosis Treatment – A Mini ReviewSemantic proximity Read

Emerging insights into the role of matrix metalloproteases as therapeutic targets in fibrosisSemantic proximity Read

The Emerging Role of Epigenetic Mechanisms in the Causation of Aberrant MMP Activity during Human Pathologies and the Use of Medicinal DrugsSemantic proximity Read

The emerging role of proteases in α1-antitrypsin deficiency and beyondSemantic proximity Read

Circulating biomarkers reflecting type III, IV and VI collagen remodeling are present in lung tissue of patients with pulmonary fibrosis and non-fibrotic controlsSemantic proximity Read