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Article

Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing.

PloS one - 1 Jan 2015

Marinova Irina N, Engelbrecht Jacob, Ewald Adrian, Langholm Lasse L, Holmberg Christian, Kragelund Birthe B, Gordon Colin, Nielsen Olaf, Hartmann-Petersen Rasmus

Abstract excerpt

The protein called p97 in mammals and Cdc48 in budding and fission yeast is a homo-hexameric, ring-shaped, ubiquitin-dependent ATPase complex involved in a range of cellular functions, including protein degradation, vesicle fusion, DNA repair, and cell division. The cdc48+ gene is essential for viability in fission yeast, and point mutations in the human orthologue have been linked to disease. To analyze the...

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Identifiers

PMID: 25658828
DOI: 10.1371/journal.pone.0117779
PMCID: PMC4319823

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Source receipt: pubmed, retrieved 7 Sept 2026.

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