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Article

Rescue of growth defects of yeast cdc48 mutants by pathogenic IBMPFD-VCPs.

Journal of structural biology - 1 Aug 2012

Takata Takahiro, Kimura Yoko, Ohnuma Yohei, Kawawaki Junko, Kakiyama Yukie, Tanaka Keiji, Kakizuka Akira

Abstract excerpt

VCP/p97/Cdc48 is a hexameric ring-shaped AAA ATPase that participates in a wide variety of cellular functions. VCP is a very abundant protein in essentially all types of cells and is highly conserved among eukaryotes. To date, 19 different single amino acid-substitutions in VCP have been reported to cause IBMPFD (inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia), an...

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Source

Identifiers

PMID: 22728077
DOI: 10.1016/j.jsb.2012.06.005

Genes

VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rescue of growth defects of yeast cdc48 mutants by pathogenic IBMPFD-VCPs.PMID 22728077Read ↗

Recent advances in p97/VCP/Cdc48 cellular functions.Semantic proximity Read ↗

A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization.Semantic proximity Read ↗

ATP-bound form of the D1 AAA domain inhibits an essential function of Cdc48p/p97.Semantic proximity Read ↗

TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.Semantic proximity Read ↗

Mechanisms of Cdc48/VCP-mediated cell death: from yeast apoptosis to human disease.Semantic proximity Read ↗

Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease.Semantic proximity Read ↗

Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model.Semantic proximity Read ↗

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.Semantic proximity Read ↗

Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and boneSemantic proximity Read ↗

Different dynamic movements of wild‐type and pathogenic <scp>VCP</scp>s and their cofactors to damaged mitochondria in a <scp>P</scp>arkin‐mediated mitochondrial quality control systemSemantic proximity Read ↗

IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation.Semantic proximity Read ↗

Structural and functional deviations in disease-associated p97 mutants.Semantic proximity Read ↗

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