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Malignant Mesothelioma, BAP1 Immunohistochemistry, and VEGFA: Does BAP1 Have Potential for Early Diagnosis and Assessment of Prognosis?

Disease markers - 1 Jan 2017

Pulford Emily, Huilgol Kalyani, Moffat David, Henderson Douglas W, Klebe Sonja

Abstract excerpt

Malignant mesothelioma (MM) is an aggressive malignancy of the serosal membranes. Early diagnosis and accurate prognostication remain problematic. BAP1 is a tumour suppressor gene commonly mutated in MM. Germline BAP1 mutation has been associated with early onset and less aggressive disease compared with sporadic MM. Sporadic BAP1 mutations are common and are associated with improved survival in MM, contrary to...

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Source

Open in PubMed Open full text

Identifiers

PMID: 29085180
DOI: 10.1155/2017/1310478
PMCID: PMC5612603

Genes

BAP1
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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