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Article

The cerebral cavernous malformation 3 gene is necessary for senescence induction.

Aging cell - 1 Apr 2015

Guerrero Ana, Iglesias Cristina, Raguz Selina, Floridia Ebel, Gil Jesús, Pombo Celia M, Zalvide Juan

Abstract excerpt

Mutations in cerebral cavernous malformation 3 gene are known to result in development of vascular malformations and have recently been proposed to also give rise to meningiomas. We report in this study that lack of CCM3 unexpectedly impairs the senescence response of cells, and this is related t...

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Identifiers

PMID: 25655101
DOI: 10.1111/acel.12316
PMCID: PMC4364839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25655101-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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