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Article

An Arf-Egr-C/EBPβ pathway linked to ras-induced senescence and cancer.

Molecular and cellular biology - 1 Mar 2015

Salotti Jacqueline, Sakchaisri Krisada, Tourtellotte Warren G, Johnson Peter F

Abstract excerpt

Oncogene-induced senescence (OIS) protects normal cells from transformation by Ras, whereas cells lacking p14/p19(Arf) or other tumor suppressors can be transformed. The transcription factor C/EBPβ is required for OIS in primary fibroblasts but is downregulated by H-Ras(V12) in immortalized NIH 3T3 cells through a mechanism involving p19(Arf) loss. Here, we report that members of the serum-induced early growth...

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3T3 Cells
Cell Transformation, Neoplastic
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p16
Early Growth Response Protein 1

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PMID: 25535333
DOI: 10.1128/MCB.01489-14
PMCID: PMC4323493

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