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Article

CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation.

Journal of cell science - 15 Apr 2010

Fidalgo Miguel, Fraile María, Pires Ana, Force Thomas, Pombo Celia, Zalvide Juan

Abstract excerpt

Mutations in CCM3/PDCD10 result in cerebral cavernous malformations (CCMs), a major cause of cerebral hemorrhage. Despite intense interest in CCMs, very little is known about the function of CCM3. Here, we report that CCM3 is located on the Golgi apparatus, forming a complex with proteins of the germinal center kinase III (GCKIII) family and GM130, a Golgi-resident protein. Cells depleted of CCM3 show a...

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Source

Identifiers

PMID: 20332113
DOI: 10.1242/jcs.061341

Genes

PDCD10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation.PMID 20332113Read ↗

CCM3/PDCD10 Heterodimerizes with Germinal Center Kinase III (GCKIII) Proteins Using a Mechanism Analogous to CCM3 HomodimerizationSemantic proximity Read ↗

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Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.Semantic proximity Read ↗

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