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Article

Sulindac metabolites decrease cerebrovascular malformations in CCM3 -knockout mice

24 Jun 2015

Abstract excerpt

Cerebral cavernous malformation (CCM) is a disease of the central nervous system causing hemorrhage-prone multiple lumen vascular malformations and very severe neurological consequences. At present, the only recommended treatment of CCM is surgical. Because surgery is often not applicable, pharmacological treatment would be highly desirable. We describe here a murine model of the disease that develops after...

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PMID: 26109568
DOI: 10.1073/pnas.1501352112

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