Article
Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database.
Journal of neuropathology and experimental neurology - 1 Mar 2016
Ringman John M, Monsell Sarah, Ng Denise W, Zhou Yan, Nguyen Andy, Coppola Giovanni, Van Berlo Victoria, Mendez Mario F, Tung Spencer, Weintraub Sandra, Mesulam Marek-Marsel, Bigio Eileen H, Gitelman Darren R, Fisher-Hubbard Amanda O, Albin Roger L, Vinters Harry V
Abstract excerpt
Alzheimer disease (AD) represents a genetically heterogeneous entity. To elucidate neuropathologic features of autosomal dominant AD ([ADAD] due to PSEN1, APP, or PSEN2 mutations), we compared hallmark AD pathologic findings in 60 cases of ADAD and 120 cases of sporadic AD matched for sex, race, ethnicity, and disease duration. Greater degrees of neuritic plaque and neurofibrillary tangle formation and cerebral...
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