Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiency of Capicua disrupts bile acid homeostasis.

Scientific reports - 5 Feb 2015

Kim Eunjeong, Park Sungjun, Choi Nahyun, Lee Jieon, Yoe Jeehyun, Kim Soeun, Jung Hoe-Yune, Kim Kyong-Tai, Kang Hyojin, Fryer John D, Zoghbi Huda Y, Hwang Daehee, Lee Yoontae

Abstract excerpt

Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown. Here we show that Cic hypomorphic (Cic-L(-/-)) mice have impaired bile acid (BA) homeostasis associated with induction of proinflammatory cytokines. We discovered that several drug metabolism and BA transporter genes were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bile Acids and Salts
Share to Blood Chemical Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokines

Share to Homeostasis

Share to Inflammation Mediators

Share to Mice, Knockout

Share to Repressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25653040
DOI: 10.1038/srep08272
PMCID: PMC4317698

Genes

CIC
FOXA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Deficiency of Capicua disrupts bile acid homeostasis.PMID 25653040Read ↗

Relative contributions of L-FABP, SCP-2/SCP-x, or both to hepatic biliary phenotype of female mice.Semantic proximity Read ↗

Absence of muricholic acid due to Cyp2c-deficiency protects against high fat diet-induced obesity in male mice but promotes liver damageSemantic proximity Read ↗

Baat-Deficient Mice Recapitulate Elevated 7α-Hydroxy-3-Oxo-4-Cholestenoic Acid Observed in a Japanese Patient With BAAT Deficiency.Semantic proximity Read ↗

Of mice and men: murine bile acids explain species differences in the regulation of bile acid and cholesterol metabolism.Semantic proximity Read ↗

Notch Signaling Regulates Bile Duct Morphogenesis in MiceSemantic proximity Read ↗

Differential response of the liver to bile acid treatment in a mouse model of Niemann-Pick disease type CSemantic proximity Read ↗

Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice.Semantic proximity Read ↗

Bile Acid Sequestration by Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in <em>Cyp2c70<sup>-/-</sup></em> Mice with a Human-Like Bile Acid CompositionSemantic proximity Read ↗

Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage.Semantic proximity Read ↗

Cubilin expression is monoallelic and epigenetically augmented via PPARs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.