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Article

Cubilin expression is monoallelic and epigenetically augmented via PPARs.

BMC genomics - 18 Jun 2013

Aseem Obaidullah, Barth Jeremy L, Klatt Sandra C, Smith Brian T, Argraves W Scott

Abstract excerpt

BACKGROUND: Cubilin is an endocytic receptor that is necessary for renal and intestinal absorption of a range of ligands. Endocytosis mediated by cubilin and its co-receptor megalin is the principal mechanism for proximal tubule reabsorption of proteins from the glomerular filtrate. Cubilin is also required for intestinal endocytosis of intrinsic factor-vitamin B12 complex. Despite its importance, little is known...

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Identifiers

PMID: 23773363
DOI: 10.1186/1471-2164-14-405
PMCID: PMC3706236

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