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Article

Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage.

Hepatology (Baltimore, Md.) - 1 Feb 2007

Loomes Kathleen M, Russo Pierre, Ryan Matthew, Nelson Anthony, Underkoffler Lara, Glover Curtis, Fu Hong, Gridley Thomas, Kaestner Klaus H, Oakey Rebecca J

Abstract excerpt

UNLABELLED: The Notch signaling pathway is involved in determination of cell fate and control of cell proliferation in multiple organ systems. Jag1 encodes a ligand in the Notch pathway and has been identified as the disease-causing gene for the developmental disorder Alagille syndrome. Evidence from the study of human disease and mouse models has implicated Jag1 as having an important role in the development of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Calcium-Binding Proteins

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Source

Identifiers

PMID: 17366661
DOI: 10.1002/hep.21460

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage.PMID 17366661Read ↗

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Sox9 Is a Modifier of the Liver Disease Severity in a Mouse Model of Alagille SyndromeSemantic proximity Read ↗

Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome.Semantic proximity Read ↗

Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopySemantic proximity Read ↗

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