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Article

Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 2004

Matsusue Kimihiko, Gavrilova Oksana, Lambert Gilles, Brewer H Bryan, Ward Jerrold M, Inoue Yusuke, LeRoith Derek, Gonzalez Frank J

Abstract excerpt

CCAAT/enhancer binding protein alpha (C/EBP alpha) is a critical factor in glucose metabolism in the neonate as revealed by conventional C/EBP alpha-null mice that do not survive beyond the first day after birth because of severe hypoglycemia and a deficiency in hepatic glycogen accumulation. To elucidate the function of C/EBP alpha in leptin-deficient mouse (ob/ob) liver, a C/EBP alpha-liver null mouse on an...

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Source

Identifiers

PMID: 15319454
DOI: 10.1210/me.2004-0213

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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