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Article

Overexpression of α1,6-fucosyltransferase in hepatoma enhances expression of Golgi phosphoprotein 2 in a fucosylation-independent manner.

International journal of oncology - 1 Jul 2011

Kawamoto Sayuri, Moriwaki Kenta, Nakagawa Tsutomu, Terao Mika, Shinzaki Shinichiro, Yamane-Ohnuki Naoko, Satoh Mitsuo, Mehta Anand S, Block Timothy M, Miyoshi Eiji

Abstract excerpt

Golgi phosphoprotein 2 (GP73) is a type II Golgi protein, which was found on examination of the fucosylated proteome as a potential tumor marker for hepatocellular carcinoma (HCC). The serum levels of both total and fucosylated GP73 were increased in the sera of patients with HCC. Fucosylation is one of the most important oligosaccharide modifications involved in cancer and is catalyzed by α1,6-fucosyltransferase...

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Identifiers

PMID: 21503570
DOI: 10.3892/ijo.2011.1005
PMCID: PMC3095700

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