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The isomerase Rrd1 mediates rapid loss of the Sgs1 helicase in response to rapamycin.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Jun 2011

Marrakchi Rim, Chouchani Chedly, Cherif Mohamed, Boudabbous Abdellatif, Ramotar Dindial

Abstract excerpt

In Saccharomyces cerevisiae , rapamycin exposure inhibits the target of rapamycin (TOR) signaling pathway, causing a profound alteration in the transcription pattern of many genes, including those involved in ribosome biogenesis and nutritional changes. Deletion of the RRD1 gene encoding a peptidyl prolyl isomerase resulted in mutants that are resistant to rapamycin. These rrd1Δ mutants are unable to efficiently...

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PMID: 21639830
DOI: 10.1139/o11-006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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