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Article

Cardiac hypertrophy induced by active Raf depends on Yorkie-mediated transcription.

Science signaling - 3 Feb 2015

Yu Lin, Daniels Joseph P, Wu Huihui, Wolf Matthew J

Abstract excerpt

Organ hypertrophy can result from enlargement of individual cells or from cell proliferation or both. Activating mutations in the serine-threonine kinase Raf cause cardiac hypertrophy and contribute to Noonan syndrome in humans. Cardiac-specific expression of activated Raf also causes hypertrophy...

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Share to Cardiomegaly
Share to Co-Repressor Proteins
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Organ Size

Share to Proto-Oncogene Proteins c-raf

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Share to YAP-Signaling Proteins

Source

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Identifiers

PMID: 25650441
DOI: 10.1126/scisignal.2005719
PMCID: PMC5131564

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25650441-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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