Article

The nutrient sensor CRTC & Sarcalumenin / Thinman represent a new pathway in cardiac hypertrophy

2023-10-02

Abstract excerpt

<h4>ABSTRACT</h4> Obesity and type 2 diabetes are at epidemic levels and a significant proportion of these patients are diagnosed with left ventricular hypertrophy. CREB R egulated T ranscription C o-activator ( CRTC ) is a key regulator of metabolism in mammalian hepatocytes, where it is activated by calcineurin (CaN) to increase expression of gluconeogenic genes. CaN is known its role in pathological cardi...

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Literature Corpus work: 693351cc-dd4d-5ce9-b9fb-31d0b317bd0a
DOI: 10.1101/2023.10.02.560407

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