Helicobacter pylori CagA: analysis of sequence diversity in relation to phosphorylation motifs and implications for the role of CagA as a virulence factor.

Abstract excerpt

CagA is transported into host target cells and subsequently phosphorylated. Clearly this is a mechanism by which Helicobacter pylori could take control of one or more host cell signal transduction pathways. Presumably the end result of this interaction favors survival of H. pylori, irrespective of eventual damage to the host cell. CagA is noted for its amino acid (AA) sequence diversity, both within and outside...

Topics

• Amino Acid Motifs
• Amino Acid Sequence
• Antigens, Bacterial
• Bacterial Proteins
• Cyclic AMP
• Genetic Variation
• Helicobacter pylori
• Humans
• Mannose-Binding Lectins
• Membrane Proteins
• Molecular Sequence Data