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Article

Characterization of East-Asian Helicobacter pylori encoding Western EPIYA-ABC CagA.

Journal of microbiology (Seoul, Korea) - 1 Feb 2022

Tissera Kavinda, Kim Myeong-A, Lai Jing, Angulmaduwa Sacheera, Kim Aeryun, Merrell D Scott, Kim Ji-Hye, Su Hanfu, Cha Jeong-Heon

Abstract excerpt

The polymorphic bacterial oncoprotein, CagA shows geography-dependent variation in the C-terminal Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs; East-Asian H. pylori isolates carry the ABD type while Western isolates carry the ABC type. In Western isolates, the EPIYA-C motif is sometimes found in multi-copy and this genotype is associated with disease severity. Interestingly, a small number of East-Asian H. pylori isolates...

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PMID: 34757586
DOI: 10.1007/s12275-022-1483-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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