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Article

AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes.

Frontiers in immunology - 1 Jan 2020

Tang Catherine, Bagnara Davide, Chiorazzi Nicholas, Scharff Matthew D, MacCarthy Thomas

Abstract excerpt

Somatic hypermutation (SHM) of the immunoglobulin variable (IgV) loci is a key process in antibody affinity maturation. The enzyme activation-induced deaminase (AID), initiates SHM by creating C → U mismatches on single-stranded DNA (ssDNA). AID has preferential hotspot motif targets in the context of WRC/GYW (W = A/T, R = A/G, Y = C/T) and particularly at WGCW overlapping hotspots where hotspots appear opposite...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to Complementarity Determining Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32425948
DOI: 10.3389/fimmu.2020.00788
PMCID: PMC7204545

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