Article

Ciliary Hedgehog signaling regulates cell survival to build the facial midline

2021-03-18

Abstract excerpt

Craniofacial defects are among the most common phenotypes caused by ciliopathies, yet the developmental and molecular etiology of these defects is poorly understood. We investigated multiple mouse models of human ciliopathies (including Tctn2, Cc2d2a and Tmem231 mutants ) and discovered that each displays hypotelorism, a narrowing of the midface. As early in development as the end of gastrulation, Tctn2 mutant...

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Literature Corpus work: ac3ca950-4088-5ab4-932f-f6dedee88977
DOI: 10.1101/2021.03.18.436057

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