Article
DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling.
Molecular psychiatry - 1 Dec 2015
Northcutt A L, Hutchinson M R, Wang X, Baratta M V, Hiranita T, Cochran T A, Pomrenze M B, Galer E L, Kopajtic T A, Li C M, Amat J, Larson G, Cooper D C, Huang Y, O'Neill C E, Yin H, Zahniser N R, Katz J L, Rice K C, Maier S F, Bachtell R K, Watkins L R
Abstract excerpt
The initial reinforcing properties of drugs of abuse, such as cocaine, are largely attributed to their ability to activate the mesolimbic dopamine system. Resulting increases in extracellular dopamine in the nucleus accumbens (NAc) are traditionally thought to result from cocaine's ability to block dopamine transporters (DATs). Here we demonstrate that cocaine also interacts with the immunosurveillance receptor...
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