Article

Chronic cocaine exposure negatively impacts Long-COVID-like outcomes produced by the SARS-CoV-2 spike protein in the rat

2026-06-02

Abstract excerpt

Acute COVID-19 outcomes are exacerbated by substance use, however, the impact of substance use on Long-COVID is unknown. Here, we investigated the impact of chronic cocaine administration on spike-induced Long-COVID-like outcomes in the rat. Rats received intermittent chronic cocaine administration and a single intravenous injection of the SARS-CoV-2 spike protein. Two months following spike administration, Long-C...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3605bed4-d99e-53c2-b775-ecc41dcf5f14
DOI: 10.64898/2026.06.02.729575

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chronic cocaine exposure negatively impacts Long-COVID-like outcomes produced by the SARS-CoV-2 spike protein in the ratDOI 10.64898/2026.06.02.729575Read

Outcomes of Patients with COVID-19 in the Setting of Chronic Opioid Use DisorderSemantic proximity Read

Effects of access condition on substance use disorder-like phenotypes in male and female rats self-administering MDPV or cocaine.Semantic proximity Read

Polysubstance addiction and psychiatric, somatic comorbidities among 7,989 individuals with cocaine use disorder: a latent class analysisSemantic proximity Read

Prefrontal circHomer1 regulates synaptic and behavioral adaptations induced by psychostimulantsSemantic proximity Read

Investigating the role of opium consumption in the severity, and outcome of COVID-19Semantic proximity Read

Effects of access condition on substance use disorder-like phenotypes in male and female rats self-administering MDPV or cocaineSemantic proximity Read

Ibrutinib as a Potential Therapeutic for Cocaine Use DisorderSemantic proximity Read

The gut microbiome is associated with cocaine behavior and predicts addiction vulnerability in adult male ratsSemantic proximity Read

Reward Circuit Adaptations After Chronic Antipsychotic Treatment Confer Addiction VulnerabilitySemantic proximity Read

Substance use, and substance use disorder, in relation to COVID-19: Protocol for a scoping reviewSemantic proximity Read

Neurogenesis inhibition restores cocaine withdrawal-induced depression via Rac1 mediationSemantic proximity Read

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock ratsSemantic proximity Read