Interaction between 5-HTTLPR genotype and cognitive stress vulnerability on sleep quality: effects of sub-chronic tryptophan administration.

doi:10.1093/ijnp/pyu057

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Article

Interaction between 5-HTTLPR genotype and cognitive stress vulnerability on sleep quality: effects of sub-chronic tryptophan administration.

The international journal of neuropsychopharmacology - 2 Feb 2015

van Dalfsen Jens H, Markus C Rob

Abstract excerpt

BACKGROUND: Abundant evidence suggests that allelic variation in the serotonin transporter-linked polymorphic region (5-HTTLPR) influences susceptibility to stress and its affective consequences due to brain serotonergic vulnerability. Based on recent assumptions, the present study examined whether the 5-HTTLPR genotype may also interact with a vulnerability to chronic stress experience (conceptualized by trait...

Topics

Adult
Analysis of Variance
Antidepressive Agents, Second-Generation
Anxiety Disorders
Double-Blind Method
Female
Genotype
Humans
Life Change Events
Male
Neuroticism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Personality Inventory

Psychiatric Status Rating Scales

Serotonin Plasma Membrane Transport Proteins

Sleep Wake Disorders

Tryptophan

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 25644221
DOI: 10.1093/ijnp/pyu057
PMCID: PMC4360245

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