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Article

Adjusting for heritable covariates can bias effect estimates in genome-wide association studies.

American journal of human genetics - 5 Feb 2015

Aschard Hugues, Vilhjálmsson Bjarni J, Joshi Amit D, Price Alkes L, Kraft Peter

Abstract excerpt

In recent years, a number of large-scale genome-wide association studies have been published for human traits adjusted for other correlated traits with a genetic basis. In most studies, the motivation for such an adjustment is to discover genetic variants associated with the primary outcome independently of the correlated trait. In this report, we contend that this objective is fulfilled when the tested variants...

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Identifiers

PMID: 25640676
DOI: 10.1016/j.ajhg.2014.12.021
PMCID: PMC4320269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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