Article

Consequence of adjustments for demographic or clinical covariates and a recommended solution in genome-wide association studies

2021-12-09

Abstract excerpt

Genome-wide association study (GWAS) is fundamentally designed to detect disease-causing genes. To reduce spurious associations or improve statistical power, about 80% of GWASs arbitrarily adjusted for demographic or clinical covariates. However, adjustment strategies in GWASs have not achieved consistent conclusions. Given the initial aim of GWAS that is to identify the causal association between a specific causa...

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Literature Corpus work: ccffe961-d07d-50ea-9fb1-98fc61397f6c
DOI: 10.1101/2021.12.07.471675

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