Article
On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects.
Genetic epidemiology - 1 Jul 2009
Vansteelandt Stijn, Goetgeluk Sylvie, Lutz Sharon, Waldman Irwin, Lyon Helen, Schadt Eric E, Weiss Scott T, Lange Christoph
Abstract excerpt
In genetic association studies, different complex phenotypes are often associated with the same marker. Such associations can be indicative of pleiotropy (i.e. common genetic causes), of indirect genetic effects via one of these phenotypes, or can be solely attributable to non-genetic/environmental links between the traits. To identify the phenotypes with the inducing genetic association, statistical methodology...
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