Article
Genome-wide mapping of histone H3K9me2 in acute myeloid leukemia reveals large chromosomal domains associated with massive gene silencing and sites of genome instability.
PloS one - 1 Jan 2017
Salzberg Anna C, Harris-Becker Abigail, Popova Evgenya Y, Keasey Nikki, Loughran Thomas P, Claxton David F, Grigoryev Sergei A
Abstract excerpt
A facultative heterochromatin mark, histone H3 lysine 9 dimethylation (H3K9me2), which is mediated by histone methyltransferases G9a/GLP (EHMT2/1), undergoes dramatic rearrangements during myeloid cell differentiation as observed by chromatin imaging. To determine whether these structural transitions also involve genomic repositioning of H3K9me2, we used ChIP-sequencing to map genome-wide topography of H3K9me2 in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.