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Article

MiR-24 Is Required for Hematopoietic Differentiation of Mouse Embryonic Stem Cells

29 Jan 2015

Abstract excerpt

Overexpression of miRNA, miR-24, in mouse hematopoietic progenitors increases monocytic/ granulocytic differentiation and inhibits B cell development. To determine if endogenous miR-24 is required for hematopoiesis, we antagonized miR-24 in mouse embryonic stem cells (ESCs) and performed in vitro differentiations. Suppression of miR-24 resulted in an inability to produce blood and hematopoietic progenitors (HPCs)...

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PMID: 25634354
DOI: 10.1371/journal.pgen.1004959

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