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Article

microRNA-22 promotes megakaryocyte differentiation through repression of its target, GFI1

7 Jan 2019

Abstract excerpt

Abstract Precise control of microRNA expression contributes to development and the establishment of tissue identity, including in proper hematopoietic commitment and differentiation, whereas aberrant expression of various microRNAs has been implicated in malignant transformation. A small number of microRNAs are upregulated in megakaryocytes, among them is microRNA-22 (miR-22). Dysregulation of miR-22 leads to...

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PMID: 30617215
DOI: 10.1182/bloodadvances.2018023804

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