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Spatial stochastic models of cancer: fitness, migration, invasion.

Mathematical biosciences and engineering : MBE - 1 Jun 2013

Komarova Natalia L

Abstract excerpt

Cancer progression is driven by genetic and epigenetic events giving rise to heterogeneity of cell phenotypes, and by selection forces that shape the changing composition of tumors. The selection forces are dynamic and depend on many factors. The cells favored by selection are said to be more 'fit'than others. They tend to leave more viable offspring and spread through the population. What cellular...

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PMID: 23906148
DOI: 10.3934/mbe.2013.10.761

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