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Article

The Ras-ERK1/2 signaling pathway regulates H3K9ac through PCAF to promote the development of pancreatic cancer.

Life sciences - 1 Sept 2020

Li Yu-Hong, Li Ying-Xue, Li Mu, Song Shao-Wei, Ge Yang, Jin Jun-Yi, Li Xiao-Ying, Tan Xiao-Dong, Ye Jing

Abstract excerpt

AIMS: The regulation of the Ras-ERK pathway is the crucial point in pancreatic carcinogenesis, and the Ras kinase is an essential regulatory upstream signal molecule of the ERK1/2 pathway. H3K9ac is a vital histone modification, but its specific role in pancreatic cancer remains unclear. This research aims to study whether the modification level of H3K9ac can regulate the characteristic phenotype of the...

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Identifiers

PMID: 32531376
DOI: 10.1016/j.lfs.2020.117936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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