Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer driver candidate genes AVL9, DENND5A and NUPL1 contribute to MDCK cystogenesis

15 Dec 2014

Abstract excerpt

AVL9, DENND5A and NUPL1 are among the cancer driver candidate genes previously identified via dog-human comparison, and may function in epithelial cell polarity as indicated by bioinformatics analysis. To better understand their cellular functions and roles in cancer, we knocked down each gene in MDCKII cells through shRNA and performed three-dimensional culture. Compared to the control, the knockdown clones...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Hippo pathway signaling and YAP/TAZ
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25621300
DOI: 10.18632/oncoscience.107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer driver candidate genes AVL9, DENND5A and NUPL1 contribute to MDCK cystogenesisPMID 25621300Read ↗

Comprehensive analysis indicated that NDE1 is a potential biomarker for pan‐cancer and promotes bladder cancer progressionSemantic proximity Read ↗

Pancreatic cyst development: insights from von Hippel-Lindau diseaseSemantic proximity Read ↗

CLDN6: From Traditional Barrier Function to Emerging Roles in CancersSemantic proximity Read ↗

Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-Dubé syndrome cell models through transcriptomic and proteomic analysisSemantic proximity Read ↗

Loss-of-function Mutations K11E or E271K Lead to Novel Tumor Suppression, Implicate Nucleolar Helicase DDX24 Oncogenicity.Semantic proximity Read ↗

Establishment of an experimental model of normal dog bladder organoid using a three-dimensional culture methodSemantic proximity Read ↗

NINJ1 promotes lung adenocarcinoma progression via activation of the PI3K-AKT signaling axis and suppression of cell death pathwaysSemantic proximity Read ↗

Identification of ADPKD-Related Genes and Pathways in Cells Overexpressing PKD2.Semantic proximity Read ↗

NudCL2 suppresses pancreatic cancer progression by inhibiting SLC7A11-mediated EMT and metastasisSemantic proximity Read ↗

Identification of the ASPM-miR-26b-5p network associated with the aggressive traits of HCC cellsSemantic proximity Read ↗

Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-Dubé syndrome through transcriptiomic and proteomic analysisSemantic proximity Read ↗

Transcriptomic Profiling Reveals Claudin 18.2 as a Diagnostic Biomarker of Ménétrier’s Disease and the Role of Hedgehog Signaling in PathogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.