Article
Loss-of-function Mutations K11E or E271K Lead to Novel Tumor Suppression, Implicate Nucleolar Helicase DDX24 Oncogenicity.
International journal of medical sciences - 1 Jan 2022
Li Xinglin, Chen Xiaoyun, Gao Jiebing, Xian Jianzhong, Li Zhijun, Bi Lei, Yang Min, Yang Shuai, Jin Hongjun, Shan Hong
Abstract excerpt
Purpose: Mutations (K11E or E271K) of DEAD-box RNA helicase 24 (DDX24) were related to multi-organ venous lymphatic malformation syndrome (MOVLD). However, the relationship between these mutations and DDX24-function still remains unknown. Understanding whether K11E and E271K cause "loss-of-function" or "gain-of-function" for DDX24 is significant for related diseases. DDX24 was reported to be related to tumors...
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