Article

Transcriptomic Profiling Reveals Claudin 18.2 as a Diagnostic Biomarker of Ménétrier’s Disease and the Role of Hedgehog Signaling in Pathogenesis

2023-11-06

Abstract excerpt

<h4>ABSTRACT</h4> Both Ménétrier’s disease (MD) and juvenile polyposis syndrome (JPS) are rare premalignant conditions that can lead to gastric cancer development. MD is an acquired disease without known causative mutations. MD patients are characterized by an increased expression of EGF receptor (EGFR) ligand and transforming growth factor alpha (TGF-α) in the stomach. JPS is inherited in an autosomal dominant p...

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Literature Corpus work: 0b7c10bb-270f-5c79-8098-290daef645d5
DOI: 10.1101/2023.11.03.565570

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