Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homozygosity mapping in an Irish ALS case-control cohort describes local demographic phenomena and points towards potential recessive risk loci.

Genomics - 1 Apr 2015

McLaughlin Russell L, Kenna Kevin P, Vajda Alice, Heverin Mark, Byrne Susan, Donaghy Colette G, Cronin Simon, Bradley Daniel G, Hardiman Orla

Abstract excerpt

Runs of homozygosity are common in European populations and are indicative of consanguinity, restricted population size and recessively inherited traits. Here, we map runs of homozygosity (ROHs) in an Irish case-control cohort for amyotrophic lateral sclerosis (ALS), a devastating neurological co...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Demography
Share to Genes, Recessive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Genome, Human

Share to Ireland

Share to White People

Source

Identifiers

PMID: 25620680
DOI: 10.1016/j.ygeno.2015.01.002

Genes

ARHGEF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25620680-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homozygosity mapping in an Irish ALS case-control cohort describes local demographic phenomena and points towards potential recessive risk loci.PMID 25620680Read ↗

A genome-wide association study of sporadic ALS in a homogenous Irish population.Semantic proximity Read ↗

Homozygosity analysis in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Long runs of homozygosity are associated with Alzheimer's disease.Semantic proximity Read ↗

Autosomal Recessive Alzheimer’s disease (arAD): homozygosity mapping of genomic regions containing arAD lociSemantic proximity Read ↗

Genomic patterns of homozygosity in worldwide human populations.Semantic proximity Read ↗

Second-generation Irish genome-wide association study for amyotrophic lateral sclerosis.Semantic proximity Read ↗

Regions of homozygosity and their impact on complex diseases and traits.Semantic proximity Read ↗

Genome-wide assessment identifies novel runs of homozygosity linked to Parkinson’s disease etiology across diverse ancestral populationsSemantic proximity Read ↗

Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK BiobankSemantic proximity Read ↗

Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer's disease.Semantic proximity Read ↗

Detecting regions of homozygosity to map the cause of recessively inherited disease.Semantic proximity Read ↗

Assessing Runs of Homozygosity: A comparison of SNP Array and Whole Genome Sequence low coverage dataSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.