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Article

Glibenclamide modulates microglial function and attenuates Aβ deposition in 5XFAD mice.

European journal of pharmacology - 5 Oct 2020

Ju Yeon-Joo, Kim Namkwon, Gee Min Sung, Jeon Seung Ho, Lee Danbi, Do Jimin, Ryu Jong-Sik, Lee Jong Kil

Abstract excerpt

Severe neuroinflammation is known as a main pathology of neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). In these diseases, excessive microglial activation is one of the main causes of inflammation in the central nervous system. Therefore, inhibition of activated microglia may be suggested as a treatment for neuroinflammatory diseases. Glibenclamide, known as a...

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Source

Identifiers

PMID: 32721448
DOI: 10.1016/j.ejphar.2020.173416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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