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Article

Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus.

Traffic (Copenhagen, Denmark) - 1 May 2015

Park Ji-Seon, Ji In Jung, An Hyun Joo, Kang Min-Ji, Kang Sang-Wook, Kim Dong-Hou, Yoon Seung-Yong

Abstract excerpt

The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune-modulatory receptor involved in phagocytosis and inflammation. Mutations of Q33X, Y38C and T66M cause Nasu-Hakola disease (NHD) which is characterized by early onset of dementia and bone cysts. A recent, genome-wide association study also revealed that single nucleotide polymorphism of TREM2, such as R47H, increased the risk of Alzheimer's...

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Source

Identifiers

PMID: 25615530
DOI: 10.1111/tra.12264

Genes

TREM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus.PMID 25615530Read ↗

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Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains.Semantic proximity Read ↗

Coding variants in TREM2 increase risk for Alzheimer's disease.Semantic proximity Read ↗

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Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.Semantic proximity Read ↗

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