Article

Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER–Golgi intermediate compartment

2017-06-23

Abstract excerpt

<h4>ABSTRACT</h4> Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane protein expressed on microglia within the brain. Several rare mutations in TREM2 cause an early-onset form of neurodegeneration when inherited homozygously. Here we investigate how these mutations affect the intracellular transport of TREM2. We find that most pathogenic TREM2 mutant proteins fail to undergo normal matur...

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Literature Corpus work: 00bfbe25-c447-5fdb-a21b-76bb552eadc7
DOI: 10.1101/154997

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